Expression of GM-CSF in T cells is increased in multiple sclerosis and suppressed by IFN-β therapy

J Rasouli, B Ciric, J Imitola, P Gonnella… - The Journal of …, 2015 - journals.aai.org
… , abundant GM-CSF production at the sites of CNS inflammation suggests that GM-CSF
reveal a potential mechanism of IFN-β therapy, namely suppression of GM-CSF production. …

GM-CSF production by CD4+ T cells in MS patients: regulation by regulatory T cells and vitamin D

E Peelen, AH Muris, J Damoiseaux… - Journal of …, 2015 - Elsevier
Multiple sclerosis (MS) is an inflammatory disease of the … patients in remission and on IFN-β
therapy were included in the … study already strongly suppressed the GM-CSF protein levels …

[HTML][HTML] Increased IL-2 and reduced TGF-β upon T-cell stimulation are associated with GM-CSF upregulation in multiple immune cell types in multiple sclerosis

J Aram, N Frakich, E Morandi, M Alrouji… - Biomedicines, 2020 - mdpi.com
GM-CSF may be a potential therapeutic target in MS. … Our finding of increased GM-CSF
expression in NK cells in … anti-IL-2 suppresses it and not only in Th cells but also other cell types. …

GM-CSF and CXCR4 define a T helper cell signature in multiple sclerosis

…, F Piehl, M Claassen, T Derfuss, T Olsson… - Nature medicine, 2019 - nature.com
… slightly increased GM-CSF expression by γδ T cells and a … of T cells, and in particular of T
C cells, after 1 year of treatment. We … of MS without unspecific collateral immune suppression. …

IL-27 mediates the response to IFN-β therapy in multiple sclerosis patients by inhibiting Th17 cells

CM Sweeney, R Lonergan, SA Basdeo… - Brain, behavior, and …, 2011 - Elsevier
… We show that IFN-β suppresses Th17 cells either directly or … DC were differentiated from
monocytes using GM-CSF and IL… IFN-β and IL-27 exerted similar effects on DC and T cell

[HTML][HTML] IFN-β acts on monocytes to ameliorate CNS autoimmunity by inhibiting proinflammatory cross-talk between monocytes and Th cells

J Rasouli, G Casella, LLW Ishikawa, R Thome… - Frontiers in …, 2021 - frontiersin.org
IFN-β has been the treatment for multiple sclerosis (MS) for … patients have increased numbers
of GM-CSF + Th cells in … in GM-CSF expression by CD4 + T cells, total CD4 + T cells from …

Expression of GM-CSF in T cells is increased in multiple sclerosis and is suppressed by IFN-β therapy (BA11P. 136)

…, K Mahajan, E Mari, F Safavi, T Leist… - The Journal of …, 2015 - journals.aai.org
… , abundant GM-CSF production at the sites of CNS inflammation suggests that GM-CSF
reveal a potential mechanism of IFN-β therapy, namely suppression of GM-CSF production. …

[HTML][HTML] The presence and suppressive activity of myeloid-derived suppressor cells are potentiated after interferon-β treatment in a murine model of multiple sclerosis

C Melero-Jerez, M Suardíaz, R Lebrón-Galán… - Neurobiology of …, 2019 - Elsevier
T cell proliferation is suppressed by the production of … The T cell population is decreased
after IFN-β treatment. AC: … , as F4/80 expression was significantly inhibited in the IFN-β treated …

[HTML][HTML] Roles of GM-CSF in the pathogenesis of autoimmune diseases: an update

N Lotfi, R Thome, N Rezaei, GX Zhang… - Frontiers in …, 2019 - frontiersin.org
… responses such as multiple sclerosis (MS) and … GM-CSF + CD4 + T cells are also frequent
in the lesions of untreated MS patients and that their numbers decrease after IFN-β treatment

Glatiramer acetate and IFN-β act on dendritic cells in multiple sclerosis

Y Hussien, A Sanna, M Söderström, H Link… - Journal of …, 2001 - Elsevier
… effects on autoreactive T cells and promoting Th2 cells. It is … IFN-β synergistically suppressed
CD1a and enhanced CD86 … presence of GM-CSF and IL-4, with or without GA, or IFN-β, or …