Expression of Pax2 and patterning of the chick inner ear
Early regionalized gene expression patterns within the otocyst appear to correlate with and
contribute to development of mature otic structures. In the chick, the transcription factor Pax2
becomes restricted to the dorsal and entire medial side of the otocyst by stage 16/17. The
dorsal region of the otocyst forms the endolymphatic duct and sac (ED/ES), and the cochlear
duct is derived from the ventromedial region. In the mouse, however, Pax2 expression is
reported only in the ventromedial and not the dorsal otocyst. In Pax2 null mice, the cochlea …
contribute to development of mature otic structures. In the chick, the transcription factor Pax2
becomes restricted to the dorsal and entire medial side of the otocyst by stage 16/17. The
dorsal region of the otocyst forms the endolymphatic duct and sac (ED/ES), and the cochlear
duct is derived from the ventromedial region. In the mouse, however, Pax2 expression is
reported only in the ventromedial and not the dorsal otocyst. In Pax2 null mice, the cochlea …
Expression of Pax2 and patterning of the chick inner ear
Early regionalized gene expression patterns within the otocyst appear to correlate with and
contribute to development of mature otic structures. In the chick, the transcription factor Pax2
becomes restricted to the dorsal and entire medial side of the otocyst by stage 16/17. The
dorsal region of the otocyst forms the endolymphatic duct and sac (ED/ES), and the cochlear
duct is derived from the ventromedial region. In the mouse, however, Pax2 expression is
reported only in the ventromedial and not the dorsal otocyst. In Pax2 null mice, the cochlea …
contribute to development of mature otic structures. In the chick, the transcription factor Pax2
becomes restricted to the dorsal and entire medial side of the otocyst by stage 16/17. The
dorsal region of the otocyst forms the endolymphatic duct and sac (ED/ES), and the cochlear
duct is derived from the ventromedial region. In the mouse, however, Pax2 expression is
reported only in the ventromedial and not the dorsal otocyst. In Pax2 null mice, the cochlea …
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