Expression of retinoic acid signaling components ADH7 and ALDH1A1 is reduced in aniridia limbal epithelial cells and a siRNA primary cell based aniridia model
L Latta, K Nordström, T Stachon… - Experimental eye …, 2019 - Elsevier
PAX6-related Aniridia is a sight-threatening disease involving progression of secondary
glaucoma and aniridia related keratopathy (ARK). Change or loss of limbal epithelial
progenitors causes epithelial surface defects. We analyzed the effect of PAX6 on mRNA
expression changes with a two-step approach, as follows. First, we sequenced mRNA from
limbal epithelial cells isolated from controls and aniridia patients. Second, we confirmed the
bioinformatics and literature-based result list for a small interfering RNA (siRNA)-based …
glaucoma and aniridia related keratopathy (ARK). Change or loss of limbal epithelial
progenitors causes epithelial surface defects. We analyzed the effect of PAX6 on mRNA
expression changes with a two-step approach, as follows. First, we sequenced mRNA from
limbal epithelial cells isolated from controls and aniridia patients. Second, we confirmed the
bioinformatics and literature-based result list for a small interfering RNA (siRNA)-based …
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