Expression of vascular permeability factor/vascular endothelial growth factor in pig cerebral microvascular endothelial cells and its upregulation by adenosine
Porcine brain-derived microvascular endothelial cells (BMEC) express the mRNA of the
polypeptide mitogen vascular permeability factor/vascular endothelial growth factor
(VPF/VEGF). The VEGF mRNA expression in BMEC could be upregulated 2.5 fold after 6 h
of treatment with 5 μM adenosine and adenosine agonists. Adenosine A1 and A2 receptor
antagonists completely abolished the upregulation of the VEGF mRNA caused by
adenosine. Agents like forskolin and cAMP phosphodiesterase inhibitors which are known …
polypeptide mitogen vascular permeability factor/vascular endothelial growth factor
(VPF/VEGF). The VEGF mRNA expression in BMEC could be upregulated 2.5 fold after 6 h
of treatment with 5 μM adenosine and adenosine agonists. Adenosine A1 and A2 receptor
antagonists completely abolished the upregulation of the VEGF mRNA caused by
adenosine. Agents like forskolin and cAMP phosphodiesterase inhibitors which are known …
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