The study aims to identify factors that influence university and college students' entrepreneurial intentions in Vietnam's Mekong Delta region. The study examines entrepreneurship mindset, subjective norm, capital sources, concept development assistance, personality qualities, and perceived behavioral control of university support for a student's entrepreneurial aim. The research was conducted according to the quantitative method. The data was collected through an online survey with a sample size of 611 students from 19 universities and colleges in the Mekong Delta region. The methods that test the scale, including Cronbach Alpha Test, Structural Equation Modeling (SEM), are used to consider the correlation between the influence factors. The results of SEM analysis show that there are five main factors affecting students' entrepreneurial intention with decreasing level of influence, including the source of capital, perceived behavioral control, business development support, entrepreneurial attitude, and educational support. Besides, the results indicate that the subjective norm, personality traits, and concept development support have no impact on the intention of students toward entrepreneurship. The research also reveals that the entrepreneurial intention of students at universities and colleges has a positive relationship and is significantly affected by capital source and perceived behavioral control.