Failure to replicate an association of rs5984894 SNP in the PCDH11X gene in a collection of 1,222 Alzheimer's disease affected patients
F Lescai, C Pirazzini, G D'Agostino… - Journal of …, 2010 - content.iospress.com
Journal of Alzheimer's Disease, 2010•content.iospress.com
A recent genome-wide study on late-onset Alzheimer's disease identified a SNP
(rs5984894) on Xq21. 3 in the PCDH11X gene strongly associated with LOAD individuals of
European descent from the United States. We genotyped the same polymorphism in 1222
cases and 938 controls from central-northern Italy and could not confirm the association on
the Italian population: multivariate logistic regression adjusted for gender and APOE ε4
allele resulted in a global p value of 0.56.
(rs5984894) on Xq21. 3 in the PCDH11X gene strongly associated with LOAD individuals of
European descent from the United States. We genotyped the same polymorphism in 1222
cases and 938 controls from central-northern Italy and could not confirm the association on
the Italian population: multivariate logistic regression adjusted for gender and APOE ε4
allele resulted in a global p value of 0.56.
Abstract
A recent genome-wide study on late-onset Alzheimer’s disease identified a SNP (rs5984894) on Xq21. 3 in the PCDH11X gene strongly associated with LOAD individuals of European descent from the United States. We genotyped the same polymorphism in 1222 cases and 938 controls from central-northern Italy and could not confirm the association on the Italian population: multivariate logistic regression adjusted for gender and APOE ε4 allele resulted in a global p value of 0.56.
content.iospress.com
以上显示的是最相近的搜索结果。 查看全部搜索结果