Fast detection of high-order epistatic interactions in genome-wide association studies using information theoretic measure

S Leem, H Jeong, J Lee, K Wee, KA Sohn - Computational biology and …, 2014 - Elsevier
There are many algorithms for detecting epistatic interactions in GWAS. However, most of
these algorithms are applicable only for detecting two-locus interactions. Some algorithms
are designed to detect only two-locus interactions from the beginning. Others do not have
limits to the order of interactions, but in practice take very long time to detect higher order
interactions in real data of GWAS. Even the better ones take days to detect higher order
interactions in WTCCC data. We propose a fast algorithm for detection of high order epistatic …
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