… Mature bone cells secrete factors that influence insulin sensitivity, and fat cells synthesize …
of the bone–fat interaction suggests that novel molecules could be used as targets to enhance …

… AMPK stimulates autophagy as well as glycolysis and inhibits mammalian target of … (visceral
and subcutaneous), anorectic women have much higher vertebral marrow fat than healthy …

… Instead, this anabolic effect is thought to be partially mediated through an increased
phosphorylation of mechanistic target of rapamycin (mTOR) and downstream signalling target P70-…

… In addition, anabolic agents that target … reduces fat accumulation in bone marrow but not
in white adipose tissue [100, 101]. Thus, understanding how drugs can act on bone marrow fat …

… Bone cell progenitors, skeletal muscle cells and adipocytes share a … fat cells. These
mechanisms evolved to acquire and store fuel, and so it is no longer surprising that the skeleton …

… skeletal muscle in health and disease. The distinct signaling pathways underlying insulin-induced
and contraction-induced FAT/… , FAT/CD36 might provide a useful therapeutic target for …

… contribute to activate skeletal muscle use of intramuscular fatty acid, fat oxidation, plasma …
produced by skeletal muscle contraction has recently been identified that targets human …

… The known FAA skeletal targets are shown in Table 1. The initial findings pointing to a
role for FAAs in bone metabolism include the expression of the CB 1 and CB 2 cannabinoid …

… skeletal homeostasis. Recently, osteal macrophages emerged as vital participants in skeletal
… anabolic factors and may present a target for therapeutic intervention in inflammation-…

… responses in skeletal muscle to the transition from a fasted to fed state using a high‐fat
meal … Our findings provide evidence for early biological adaptations to high‐fat feeding that …