Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner
W Shao, CE Machamer, PJ Espenshade - Journal of lipid research, 2016 - ASBMB
Sterol regulatory element-binding protein (SREBP) transcription factors are central
regulators of cellular lipid homeostasis and activate expression of genes required for fatty
acid, triglyceride, and cholesterol synthesis and uptake. SREBP cleavage activating protein
(SCAP) plays an essential role in SREBP activation by mediating endoplasmic reticulum
(ER)-to-Golgi transport of SREBP. In the Golgi, membrane-bound SREBPs are cleaved
sequentially by the site-1 and site-2 proteases. Recent studies have shown a requirement …
regulators of cellular lipid homeostasis and activate expression of genes required for fatty
acid, triglyceride, and cholesterol synthesis and uptake. SREBP cleavage activating protein
(SCAP) plays an essential role in SREBP activation by mediating endoplasmic reticulum
(ER)-to-Golgi transport of SREBP. In the Golgi, membrane-bound SREBPs are cleaved
sequentially by the site-1 and site-2 proteases. Recent studies have shown a requirement …
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