Fibulins: a new biomarker for pulmonary thromboembolism?
The Aging Male, 2020•Taylor & Francis
Abstract Objectives Fibulin-1,-2,-4, and-5 have important role in several vascular diseases.
We aimed to investigate if fibulin-4 and-5 can be used as a biomarker for pulmonary
thromboembolism (PTE). Methods This is a prospective case control study. Thirthy patients
diagnosed with PTE and 31 in the control group. Data on demographic characteristics,
length of hospital stay, blood cell counts, troponin and BNP levels, arterial blood gases,
radiological reports, indication for thromboembolitic treatment, intensive care unit (ICU) …
We aimed to investigate if fibulin-4 and-5 can be used as a biomarker for pulmonary
thromboembolism (PTE). Methods This is a prospective case control study. Thirthy patients
diagnosed with PTE and 31 in the control group. Data on demographic characteristics,
length of hospital stay, blood cell counts, troponin and BNP levels, arterial blood gases,
radiological reports, indication for thromboembolitic treatment, intensive care unit (ICU) …
Objectives
Fibulin-1, -2, -4, and -5 have important role in several vascular diseases. We aimed to investigate if fibulin-4 and -5 can be used as a biomarker for pulmonary thromboembolism (PTE).
Methods
This is a prospective case control study. Thirthy patients diagnosed with PTE and 31 in the control group. Data on demographic characteristics, length of hospital stay, blood cell counts, troponin and BNP levels, arterial blood gases, radiological reports, indication for thromboembolitic treatment, intensive care unit (ICU) requirement, and loss of life were recorded for the patients group. Serum Fibulin-4 and Fibulin-5 levels were measured.
Results
Fibulin 4 levels correlated positively with female gender (p < .01, r = 0.433). Positive results were found in 14 (46.7%) patients for PESI.0.1; in 7 (23.3%) patients for D-dimer; in 7 (23.3%) patients for troponin-I; in 7(23.3%) patients for BNP. Median values for Fibulin 4 level were significantly higher in patients positive for BNP. Fibulin-5 level was found to be correlated with the presence of embolism (p = .041, r = 0.263).
Conclusions
Fibulin-4 and -5 have been shown to be relevant to cardiovascular biology and diseases. Experimental studies and observations in humans show that they may play a role in several cardiovascular diseases particularly pulmonary embolism.
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