In bone, a large proportion of osteoblasts, the cells responsible for deposition of new bone,
normally undergo programmed cell death (apoptosis). Because mechanical loading of bone
increases the rate of new bone formation, we hypothesized that mechanical stimulation of
osteoblasts might increase their survival. To test this hypothesis, we investigated the effects
of fluid shear stress (FSS) on osteoblast apoptosis using three osteoblast cell types: primary
rat calvarial osteoblasts (RCOB), MC3T3‐E1 osteoblastic cells, and UMR106 osteosarcoma …

Fluid shear stress inhibits TNF-alpha-induced apoptosis in osteoblasts : a role for fluid
shear stress-induced activation of PI3-kinase and inhibition of caspase-3 | CiNii Research …
Fluid shear stress inhibits TNF-alpha-induced apoptosis in osteoblasts : a role for fluid
shear stress-induced activation of PI3-kinase and inhibition of caspase-3 …