Fluorescent turn-on Zn2+ sensing in aqueous and cellular media
Sensors and Actuators B: Chemical, 2011•Elsevier
A naphthalimide-based water soluble Zn2+ sensor bearing polyamino carboxylate as a
metal chelating moiety was synthesized and its application for the selective detection of
Zn2+ ion in 100% aqueous solution is demonstrated. The newly developed fluorescent
sensor exhibits selective binding affinity towards Zn2+ and pH insensitivity in biologically
relevant range. Confocal fluorescent microscopy images indicate that this probe works
effectively for intracellular Zn2+ imaging with high cell permeability.
metal chelating moiety was synthesized and its application for the selective detection of
Zn2+ ion in 100% aqueous solution is demonstrated. The newly developed fluorescent
sensor exhibits selective binding affinity towards Zn2+ and pH insensitivity in biologically
relevant range. Confocal fluorescent microscopy images indicate that this probe works
effectively for intracellular Zn2+ imaging with high cell permeability.
A naphthalimide-based water soluble Zn2+ sensor bearing polyamino carboxylate as a metal chelating moiety was synthesized and its application for the selective detection of Zn2+ ion in 100% aqueous solution is demonstrated. The newly developed fluorescent sensor exhibits selective binding affinity towards Zn2+ and pH insensitivity in biologically relevant range. Confocal fluorescent microscopy images indicate that this probe works effectively for intracellular Zn2+ imaging with high cell permeability.
Elsevier
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