[PDF][PDF] Formulation development, in vitro and in vivo evaluation of membrane controlled transdermal systems of glibenclamide
PURPOSE: The objective of the present study was to develop the membrane controlled
transdermal systems of glibenclamide and to evaluate with respect o various in vitro and in
vivo parameters. METHODS: The membrane moderated transdermal systems were
prepared using drug containing carbopol gel as reservoir and ethyl cellulose, Eudragit RS-
100, Eudragit RL-100 and Ethylene vinyl acetate (EVA)(2%, 9% and 19% vinyl acetate
content) rate controlling membranes. The possible interaction between drug and polymer …
transdermal systems of glibenclamide and to evaluate with respect o various in vitro and in
vivo parameters. METHODS: The membrane moderated transdermal systems were
prepared using drug containing carbopol gel as reservoir and ethyl cellulose, Eudragit RS-
100, Eudragit RL-100 and Ethylene vinyl acetate (EVA)(2%, 9% and 19% vinyl acetate
content) rate controlling membranes. The possible interaction between drug and polymer …
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