Four-miRNA signature to identify asbestos-related lung malignancies
L Santarelli, S Gaetani, F Monaco, M Bracci… - … Biomarkers & Prevention, 2019 - AACR
Cancer Epidemiology, Biomarkers & Prevention, 2019•AACR
Background: Altered miRNA expression is an early event upon exposure to occupational/
environmental carcinogens; thus, identification of a novel asbestos-related profile of miRNAs
able to distinguish asbestos-induced cancer from cancer with different etiology can be useful
for diagnosis. We therefore performed a study to identify miRNAs associated with asbestos-
induced malignancies. Methods: Four groups of patients were included in the study,
including patients with asbestos-related (NSCLCAsb) and asbestos-unrelated non–small …
environmental carcinogens; thus, identification of a novel asbestos-related profile of miRNAs
able to distinguish asbestos-induced cancer from cancer with different etiology can be useful
for diagnosis. We therefore performed a study to identify miRNAs associated with asbestos-
induced malignancies. Methods: Four groups of patients were included in the study,
including patients with asbestos-related (NSCLCAsb) and asbestos-unrelated non–small …
Background
Altered miRNA expression is an early event upon exposure to occupational/environmental carcinogens; thus, identification of a novel asbestos-related profile of miRNAs able to distinguish asbestos-induced cancer from cancer with different etiology can be useful for diagnosis. We therefore performed a study to identify miRNAs associated with asbestos-induced malignancies.
Methods
Four groups of patients were included in the study, including patients with asbestos-related (NSCLCAsb) and asbestos-unrelated non–small cell lung cancer (NSCLC) or with malignant pleural mesothelioma (MPM), and disease-free subjects (CTRL). The selected miRNAs were evaluated in asbestos-exposed population.
Results
Four serum miRNAs, that is miR-126, miR-205, miR-222, and miR-520g, were found to be implicated in asbestos-related malignant diseases. Notably, increased expression of miR-126 and miR-222 were found in asbestos-exposed subjects, and both miRNAs are involved in major pathways linked to cancer development. Epigenetic changes and cancer-stroma cross-talk could induce repression of miR-126 to facilitate tumor formation, angiogenesis, and invasion.
Conclusions
This study indicates that miRNAs are potentially involved in asbestos-related malignancies, and their expression outlines mechanism(s) whereby miRNAs may be involved in an asbestos-induced pathogenesis.
Impact
The discovery of a miRNA panel for asbestos-related malignancies would impact on occupational compensation and may be utilized for screening asbestos-exposed populations.
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