Foxm1 expression in prostate epithelial cells is essential for prostate carcinogenesis
Y Cai, D Balli, V Ustiyan, L Fulford, A Hiller… - Journal of Biological …, 2013 - ASBMB
The treatment of advanced prostate cancer (PCa) remains a challenge. Identification of new
molecular mechanisms that regulate PCa initiation and progression would provide targets
for the development of new cancer treatments. The Foxm1 transcription factor is highly up-
regulated in tumor cells, inflammatory cells, and cells of tumor microenvironment. However,
its functions in different cell populations of PCa lesions are unknown. To determine the role
of Foxm1 in tumor cells during PCa development, we generated two novel transgenic mouse …
molecular mechanisms that regulate PCa initiation and progression would provide targets
for the development of new cancer treatments. The Foxm1 transcription factor is highly up-
regulated in tumor cells, inflammatory cells, and cells of tumor microenvironment. However,
its functions in different cell populations of PCa lesions are unknown. To determine the role
of Foxm1 in tumor cells during PCa development, we generated two novel transgenic mouse …
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