Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease
S Sakaguchi, M Ono, R Setoguchi, H Yagi… - Immunological …, 2006 - Wiley Online Library
Naturally arising CD25+ CD4+ regulatory T (Treg) cells, most of which are produced by the
normal thymus as a functionally mature T‐cell subpopulation, play key roles in the
maintenance of immunologic self‐tolerance and negative control of a variety of physiological
and pathological immune responses. Natural Tregs specifically express Foxp3, a
transcription factor that plays a critical role in their development and function. Complete
depletion of Foxp3‐expressing natural Tregs, whether they are CD25+ or CD25–, activates …
normal thymus as a functionally mature T‐cell subpopulation, play key roles in the
maintenance of immunologic self‐tolerance and negative control of a variety of physiological
and pathological immune responses. Natural Tregs specifically express Foxp3, a
transcription factor that plays a critical role in their development and function. Complete
depletion of Foxp3‐expressing natural Tregs, whether they are CD25+ or CD25–, activates …
[PDF][PDF] Foxp3 CD25 CD4 natural regulatory T cells in dominant self-tolerance and autoimmune
S Hori, Z Fehervari, J Shimizu, T Takahashi… - Immunological …, 2006 - academia.edu
Naturally arising CD25+CD4+ regulatory T (Treg) cells, most of which are produced by the
normal thymus as a functionally mature T-cell subpopulation, play key roles in the
maintenance of immunologic self-tolerance and negative control of a variety of physiological
and pathological immune responses. Natural Tregs specifically express Foxp3, a
transcription factor that plays a critical role in their development and function. Complete
depletion of Foxp3-expressing natural Tregs, whether they are CD25+ or CD25–, activates …
normal thymus as a functionally mature T-cell subpopulation, play key roles in the
maintenance of immunologic self-tolerance and negative control of a variety of physiological
and pathological immune responses. Natural Tregs specifically express Foxp3, a
transcription factor that plays a critical role in their development and function. Complete
depletion of Foxp3-expressing natural Tregs, whether they are CD25+ or CD25–, activates …
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