Functional properties of an alternative, tissue-specific promoter for human arylamine N-acetyltransferase 1
DF Barker, A Husain, JR Neale, BD Martini… - Pharmacogenetics …, 2006 - journals.lww.com
Variable expression of human arylamine N-acetyltransferase 1 (NAT1) due to genetic
polymorphism, gene regulation or environmental influences is associated with individual
susceptibility to various cancers. Recent studies of NAT1 transcription showed that most
mRNAs originate at a promoter, P1, located 11.8 kb upstream of the single open reading
frame (ORF) exon. We have now characterized an alternative NAT1 promoter lying 51.5 kb
upstream of the NAT1 ORF. In the present study, analysis of human RNAs representing 27 …
polymorphism, gene regulation or environmental influences is associated with individual
susceptibility to various cancers. Recent studies of NAT1 transcription showed that most
mRNAs originate at a promoter, P1, located 11.8 kb upstream of the single open reading
frame (ORF) exon. We have now characterized an alternative NAT1 promoter lying 51.5 kb
upstream of the NAT1 ORF. In the present study, analysis of human RNAs representing 27 …