Functionalized xenon as a biosensor

MM Spence, SM Rubin, IE Dimitrov… - Proceedings of the …, 2001 - National Acad Sciences
… We have developed an NMR-based xenon biosensor that … xenon to detect specific
biomolecules at the level of tens of nanomoles. We present results using xenonfunctionalized” by a …

Development of a functionalized xenon biosensor

MM Spence, EJ Ruiz, SM Rubin… - Journal of the …, 2004 - ACS Publications
functionalized xenon by exploiting the laser-polarized xenon magnetization reservoir. We
also show that the xenon chemical shifts are distinct for xenon … encapsulated xenon chemical …

Xenon for NMR biosensing–inert but alert

L Schröder - Physica Medica, 2013 - Elsevier
… NMR studies with hyperpolarized xenon as functionalized sensor or contrast agent recently
made notable progress in developing a new approach for detecting molecular markers and …

Optimization of xenon biosensors for detection of protein interactions

TJ Lowery, S Garcia, L Chavez, EJ Ruiz, T Wu… - …, 2006 - Wiley Online Library
… We envision applications of functionalized xenon to include spatially localized sensing of
specific molecules (eg metabolites, antigens, etc.) in a selective and low-background manner …

An expanded palette of xenon-129 NMR biosensors

Y Wang, IJ Dmochowski - Accounts of Chemical Research, 2016 - ACS Publications
… of well-solubilized xenon biosensors. Most recently, Kotera … xenon biosensors targeting
integrin receptors that are upregulated in many human cancers. Cryptophane was functionalized

Biosensing using laser-polarized xenon NMR/MRI

P Berthault, G Huber, H Desvaux - Progress in Nuclear Magnetic …, 2009 - Elsevier
… These host molecules will be functionalized in order to target specific receptors thanks to
a recognition antenna of the peptide type for instance. As the electronic cloud of …

[PDF][PDF] A cryptophane biosensor for the detection of specific nucleotide targets through xenon NMR spectroscopy

V Roy, T Brotin, JP Dutasta, MH Charles, T Delair… - …, 2007 - academia.edu
… for xenon,[2] and for which a dedicated chemistry has been developed for their functionalization
129Xe NMR signal, which is different from that observed with the xenon biosensor alone. …

Sensitivity enhancement by exchange mediated magnetization transfer of the xenon biosensor signal

S Garcia, L Chavez, TJ Lowery, SI Han… - Journal of Magnetic …, 2007 - Elsevier
… Here we describe an alternative exchange transfer approach for xenon biosensor detection
that intrinsically scales linearly with the number of ‘… Functionalized xenon as a biosensor

Functionalized 129 Xe as a potential biosensor for membrane fluidity

M Schnurr, C Witte, L Schröder - Physical Chemistry Chemical Physics, 2013 - pubs.rsc.org
… Using spin hyperpolarized xenon ( 129 Xe) we investigate the impact of the local molecular
environment on reversible host–guest interactions. We label Xe guest atoms that are …

[PDF][PDF] Spectrally Resolved Magnetic Resonance Imaging of the Xenon Biosensor

C Hilty, T Lowery, D Wemmer, A Pines - 2005 - escholarship.org
xenon makes possible the use of the xenon biosensor for multiplexed analysis, where a
number of different biosensors with unique xenon … of the functionalized xenon biosensor;[2,6] …