GATA and Phytochrome Interacting Factor Transcription Factors Regulate Light-Induced Vindoline Biosynthesis in Catharanthus roseus
Catharanthus roseus is the exclusive source of an array of terpenoid indole alkaloids
including the anticancer drugs vincristine and vinblastine, derived from the coupling of
catharanthine and vindoline. Leaf-synthesized vindoline is regulated by light. A seven-step
enzymatic process is involved in the sequential conversion of tabersonine to vindoline;
however, the regulatory mechanism controlling the expression of genes encoding these
enzymes has not been elucidated. Here, we identified CrGATA1, an Leu-Leu-Met domain …
including the anticancer drugs vincristine and vinblastine, derived from the coupling of
catharanthine and vindoline. Leaf-synthesized vindoline is regulated by light. A seven-step
enzymatic process is involved in the sequential conversion of tabersonine to vindoline;
however, the regulatory mechanism controlling the expression of genes encoding these
enzymes has not been elucidated. Here, we identified CrGATA1, an Leu-Leu-Met domain …
GATA and phytochrome interacting factor transcription factors regulate light-induced vindoline biosynthesis in Catharanthus roseus.
LYL Liu YongLiang, B Patra, S Pattanaik… - 2019 - cabidigitallibrary.org
Catharanthus roseus is the exclusive source of an array of terpenoid indole alkaloids
including the anticancer drugs vincristine and vinblastine, derived from the coupling of
catharanthine and vindoline. Leaf-synthesized vindoline is regulated by light. A seven-step
enzymatic process is involved in the sequential conversion of tabersonine to vindoline;
however, the regulatory mechanism controlling the expression of genes encoding these
enzymes has not been elucidated. Here, we identified CrGATA1, an Leu-Leu-Met domain …
including the anticancer drugs vincristine and vinblastine, derived from the coupling of
catharanthine and vindoline. Leaf-synthesized vindoline is regulated by light. A seven-step
enzymatic process is involved in the sequential conversion of tabersonine to vindoline;
however, the regulatory mechanism controlling the expression of genes encoding these
enzymes has not been elucidated. Here, we identified CrGATA1, an Leu-Leu-Met domain …
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