GC-MS Investigation of Amaryllidaceae Alkaloids in Galanthus xvalentinei nothosubsp. subplicatus
Natural Product Communications, 2013•journals.sagepub.com
A GC-MS analysis of alkaloids in the aerial parts and bulbs of Galanthus x valentinei
nothosubsp. subplicatus was performed for the first time. Totally, twenty-six alkaloids were
identified, of which tazettine and galanthindole were the major ones. Acetylcholinesterase
inhibitory activity of the alkaloidal extracts was determined using modified in vitro Ellman's
method. Significant anticholinesterase activity was observed in the tested samples (bulbs:
IC50= 21.3 μg/mL, aerial parts: IC50= 16.3 μg/mL).
nothosubsp. subplicatus was performed for the first time. Totally, twenty-six alkaloids were
identified, of which tazettine and galanthindole were the major ones. Acetylcholinesterase
inhibitory activity of the alkaloidal extracts was determined using modified in vitro Ellman's
method. Significant anticholinesterase activity was observed in the tested samples (bulbs:
IC50= 21.3 μg/mL, aerial parts: IC50= 16.3 μg/mL).
A GC-MS analysis of alkaloids in the aerial parts and bulbs of Galanthus xvalentinei nothosubsp. subplicatus was performed for the first time. Totally, twenty-six alkaloids were identified, of which tazettine and galanthindole were the major ones. Acetylcholinesterase inhibitory activity of the alkaloidal extracts was determined using modified in vitro Ellman's method. Significant anticholinesterase activity was observed in the tested samples (bulbs: IC50 = 21.3 μg/mL, aerial parts: IC50 = 16.3 μg/mL).
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