GWAS of 126,559 individuals identifies genetic variants associated with educational attainment
A genome-wide association study (GWAS) of educational attainment was conducted in a
discovery sample of 101,069 individuals and a replication sample of 25,490. Three
independent single-nucleotide polymorphisms (SNPs) are genome-wide significant
(rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are
small (coefficient of determination R 2≈ 0.02%), approximately 1 month of schooling per
allele. A linear polygenic score from all measured SNPs accounts for≈ 2% of the variance in …
discovery sample of 101,069 individuals and a replication sample of 25,490. Three
independent single-nucleotide polymorphisms (SNPs) are genome-wide significant
(rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are
small (coefficient of determination R 2≈ 0.02%), approximately 1 month of schooling per
allele. A linear polygenic score from all measured SNPs accounts for≈ 2% of the variance in …
GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
ND Hastie, MJHM van der Loos, V Vitart, JÃ Wellmann… - 2013 - ideas.repec.org
A genome-wide association study (GWAS) of educational attainment was conducted in a
discovery sample of 101,069 individuals and a replication sample of 25,490. Three
independent single-nucleotide polymorphisms (SNPs) are genome-wide significant
(rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are
small (coefficient of determination R2 ≠ˆ 0.02%), approximately 1 month of schooling per
allele. A linear polygenic score from all measured SNPs accounts for ≠ˆ2% of the …
discovery sample of 101,069 individuals and a replication sample of 25,490. Three
independent single-nucleotide polymorphisms (SNPs) are genome-wide significant
(rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are
small (coefficient of determination R2 ≠ˆ 0.02%), approximately 1 month of schooling per
allele. A linear polygenic score from all measured SNPs accounts for ≠ˆ2% of the …
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