… of genes in the nuclear space also influences gene expression. Radial positioning of genes
… expression, with active genes often located in the interior and silent genes at the periphery (…

… in gene positioning represent gene targeting to different subnuclear locations, or does gene
positioning … play an essential role in controlling gene positioning. The relocalization of the …

… In this Essay, we explore the biological meaning of spatial gene positioning by examining
the functional link between the activity of a gene and its radial position in the nucleus. …

… genes adopt non-random positions in the nuclear interior. We will review studies on gene
positioning … to a responsive gene on another chromosome to cause altered gene expression in …

… gene positioning and much of what we know about positioning factors relates to the proximity
of genes to … activation or repression of genes upon re-positioning to the nuclear periphery …

… gene positioning in specific compartments can have differential effects on expression. In this
section, we focus on how radial positioning and gene positioning … modulate gene expression…

The mammalian cell nucleus provides a landscape where genes are regulated through their
organization and association with freely diffusing proteins and nuclear domains. In many …

… Positioning factors include chromatin remodelers, histone … positioning factors, and timely
progression of cells through replication, but not mitosis, is required for correct gene positioning. …

… the transcriptional apparatus at some distance from a gene's transcription initiation site. …
cause classical position effects. Position effects that influence the expression of genes relocated …

… In summary, gene position inside or outside of heterochromatin and gene expression is not
… “does a gene’s location matter?” In support of this, the evidence so far shows that genes are …