In recent years there has been a great advancement in molecular biology techniques, which enabled the researches on influence of genetics on human performances in particular athletic performance. The role of genetic in sport has been discussed and ethical issue is considerable for every one that uses this technology to enhance sport performance. Talent identification, injury susceptibility and success in this field are the positive role but there is challenge to detect gene cheating. This report is a big question for technology developer to understand the end of this field and preventing any abuse of science in gene doping.