Head and neck cancer is one of the leading causes of deaths worldwide. Two genes GSTM1 and GSTT1 involvedin phase II of carcinogen detoxification have been frequently studied in the literature. Their null genotypes arethought to be associated with increased head and neck cancer risk. However, the published reviews are not upto date and many important papers have been skipped. The current literature review was restricted to the nullgenotypes of the GSTM1 and GSTT1 genes with special emphasis on the genotypic status. We found that thesize of study sample varied greatly and the oral cavity cancer was more influenced by GSTM1 and GSTT1 genedeletions. With respect to ethnicity Asians are more prone to head and neck cancers with these null genotypes ascompared to Europeans and Americans. The current review showed significant associations (OR=9.0, 95%CI;1.4-9.5; OR=3.7, 95%CI; 1.4-9.5) of GSTM1 and GSTT1 null genotypes with head and neck cancers. Reviewconfirms the data of previous reviews that GSTM1 and GSTT1 gene polymorphisms may be risk factors forcancer initiation.