… of circulating tumor cells (CTCs) from peripheral blood at single-cell resolution recapitulate
… We demonstrate that CTCs provide the same genetic information as bone marrow MM cells …

… circulating MM cells obtained by flow cytometry. We performed single-cell whole genome
amplification of single cells … 568 single primary cells representing CMMCs, BM MM cells, CD19 …

… in multiple myeloma (MM) were published 1 , the genetic … , single-cell sequencing can provide
a high-resolution examination … microenvironment, and circulating tumour cells (CTCs). a | …

… find, track, and interrogate cell types, states, and clones.… between BM PCs and circulating
tumor cells (CTCs). Lohr et al62 used … between BM cells and CTCs at single-cell resolution also …

… Multiple myeloma (MM) patients undergo repetitive bone marrow (BM) aspirates for genetic
characterization. Circulating tumor cells (CTCs) are detectable in peripheral blood (PB) of …

… to interrogate tumors at a single-cell resolution, single-cell RNA … in MM and identified
circulating tumor cells as well as … plots for average gene expression from single cell RNA …

… Genetic interrogation of circulating multiple myeloma cells at single-cell resolution. Science
Translational Medicine 8, 363ra147–363ra147. Lohr, JG, Stojanov, P., Carter, SL, Cruz-…

… Although we focused on genetic alterations, future transcriptomics studies using single-cell …
invasive detection, enumeration, and genomic interrogation of rare CTCs from the PB, …

… Multiple myeloma is an incurable malignancy that initiates … The amplified DNA fragments
with target size were sequenced … the detection of common genetic aberrations currently used as …

… follow the cancer-cell fate over time by interrogating circulating tumor cells from patients (9). …
to filter out low-quality cells: (i) library size, (ii) number of genes detected, (iii) percentage of …