Genetic loci influencing kidney function and chronic kidney disease
Nature genetics, 2010•nature.com
Using genome-wide association, we identify common variants at 2p12–p13, 6q26, 17q23
and 19q13 associated with serum creatinine, a marker of kidney function (P= 10− 10 to 10−
15). Of these, rs10206899 (near NAT8, 2p12–p13) and rs4805834 (near SLC7A9, 19q13)
were also associated with chronic kidney disease (P= 5.0× 10− 5 and P= 3.6× 10− 4,
respectively). Our findings provide insight into metabolic, solute and drug-transport
pathways underlying susceptibility to chronic kidney disease.
and 19q13 associated with serum creatinine, a marker of kidney function (P= 10− 10 to 10−
15). Of these, rs10206899 (near NAT8, 2p12–p13) and rs4805834 (near SLC7A9, 19q13)
were also associated with chronic kidney disease (P= 5.0× 10− 5 and P= 3.6× 10− 4,
respectively). Our findings provide insight into metabolic, solute and drug-transport
pathways underlying susceptibility to chronic kidney disease.
Abstract
Using genome-wide association, we identify common variants at 2p12–p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10−10 to 10−15). Of these, rs10206899 (near NAT8, 2p12–p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 × 10−5 and P = 3.6 × 10−4, respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.
nature.com
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