Genetic polymorphisms in mouse genes regulating age-sensitive and age-stable T cell subsets
To see whether genetic polymorphisms regulate inter-individual differences in T cell subset
levels, we have conducted a genome scan in two populations of mice, bred as the progeny
of a cross between CB6F1 females and C3D2F1 males. The data document quantitative trait
loci (QTL) with statistically significant effects on CD4, CD8, and CD8 memory T cells, and on
subsets of CD4 and CD8 T cells that express P-glycoprotein. Some of the loci detected were
robust, in the sense that they produced effects of similar size both in mated female mice, and …
levels, we have conducted a genome scan in two populations of mice, bred as the progeny
of a cross between CB6F1 females and C3D2F1 males. The data document quantitative trait
loci (QTL) with statistically significant effects on CD4, CD8, and CD8 memory T cells, and on
subsets of CD4 and CD8 T cells that express P-glycoprotein. Some of the loci detected were
robust, in the sense that they produced effects of similar size both in mated female mice, and …
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