过去一年中添加的文章，按日期排序
… knock-in mouse model for SARS-CoV-2 infection recapitulates respiratory disorders but avoids neurological disease associated with the transgenic K18-hACE2 model …
A Pons-Grifols, F Tarres-Freixas, M Pérez… - bioRxiv, 2024 - biorxiv.org
8 天前 - … of this KI model was started at the beginning of the COVID-19 pandemic 230 as
an alternative to the K18-hACE2 transgenic mouse model. Even though the transgenic 231 …
an alternative to the K18-hACE2 transgenic mouse model. Even though the transgenic 231 …
Characterizing a Lethal CAG-ACE2 Transgenic Mouse Model for SARS-CoV-2 infection with Using Cas9-Enhanced Nanopore Sequencing
A Smirnov, A Nurislamov, G Koncevaya, I Serova… - bioRxiv, 2024 - biorxiv.org
21 天前 - … as the primary animal model to study COVID-19 infection. … Precision genetic
modification using CRISPR/Cas9 … infected animals were used as control. Intranasal inoculation …
modification using CRISPR/Cas9 … infected animals were used as control. Intranasal inoculation …
[HTML][HTML] SARS-CoV-2 infection exacerbates the cellular pathology of Parkinson's disease in human dopaminergic neurons and a mouse model
B Lee, HN Choi, YH Che, M Ko, HM Seong, MG Jo… - Cell Reports …, 2024 - cell.com
38 天前 - … (hACE2) transgenic (Tg) mouse model. Our findings reveal that SARS-CoV-2
infection exacerbates PD susceptibility and cellular toxicity in DA neurons pre-treated with human …
infection exacerbates PD susceptibility and cellular toxicity in DA neurons pre-treated with human …
Monocyte Production of C1q Potentiates CD8+ T Cell Function Following Respiratory Viral Infection
50 天前 - … murine model and in patients with severe COVID-19. These findings are consistent
with a prior study which demonstrated gC1qR is abundantly expressed on human CD8+ T …
with a prior study which demonstrated gC1qR is abundantly expressed on human CD8+ T …
Developing a Novel Therapeutic for Smokers Infected With SARS-CoV-2
KN Castillo, M Ghannam, T Rickabaugh… - … AND COVID-19 …, 2024 - atsjournals.org
51 天前 - … two-fold higher chance of severe COVID-19 and death. … mouse model. We are
currently elucidating the toxicity and efficacy of berzosertib during smoking in these three models…
currently elucidating the toxicity and efficacy of berzosertib during smoking in these three models…
[HTML][HTML] Targeting IL-6 trans-signalling by sgp130Fc attenuates severity in SARS-CoV-2-infected mice and reduces endotheliopathy
MÁ Rodríguez-Hernández, M Baena-Bustos… - Ebiomedicine, 2024 - thelancet.com
56 天前 - … in short- and long-term consequences of COVID-19, we used the established
K18-hACE2 transgenic mouse model. Histological as well as immunohistochemical analysis, and …
K18-hACE2 transgenic mouse model. Histological as well as immunohistochemical analysis, and …
[HTML][HTML] Effect of SARS-CoV-2 S protein on the proteolytic cleavage of the epithelial Na+ channel ENaC
GR Magaña-Ávila, E Moreno, C Plata… - Plos one, 2024 - journals.plos.org
57 天前 - … Severe cases of COVID-19 are characterized by … of lungs obtained from three
uninfected control mice. … mice were used, which is a frequently used mouse model in SARS-CoV-2 …
uninfected control mice. … mice were used, which is a frequently used mouse model in SARS-CoV-2 …
SARS-CoV-2 infected human ACE2 transgenic pigs develop severe COVID-19-like pathology.
F Grey, LF Chau, S Lillico, T Opriessnig, R Blake… - 2024 - researchsquare.com
66 天前 - … Animal models that accurately reflect COVID-19 are vital for … We have developed
human ACE2 transgenic pigs that are … In contrast, control pigs showed no clinical signs of …
human ACE2 transgenic pigs that are … In contrast, control pigs showed no clinical signs of …
CD151 Maintains Endolysosomal Protein Quality to Inhibit Vascular Inflammation
81 天前 - … analyses on genetically engineered mouse models, and … pulmonary diseases or
COVID-19, endothelial CD151 … murine ANGPT2 (dissolved in PBS, 4 mg/kg, IP) or control …
COVID-19, endothelial CD151 … murine ANGPT2 (dissolved in PBS, 4 mg/kg, IP) or control …
[HTML][HTML] Preclinical evaluation of the SARS-CoV-2 Mpro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir
X Chen, X Huang, Q Ma, P Kuzmič, B Zhou… - Nature …, 2024 - nature.com
84 天前 - … ACE2 transgenic mouse models, … to combat SARS-CoV-2 immune escape. Of
note, the orally available drugs molnupiravir and Paxlovid have been approved for COVID-19 …
note, the orally available drugs molnupiravir and Paxlovid have been approved for COVID-19 …