Genome‐wide methylomic regulation of multiscale gene networks in Alzheimer's disease
INTRODUCTION Recent studies revealed the association of abnormal methylomic changes
with Alzheimer's disease (AD) but there is a lack of systematic study of the impact of
methylomic alterations over the molecular networks underlying AD. METHODS We profiled
genome‐wide methylomic variations in the parahippocampal gyrus from 201 post mortem
control, mild cognitive impaired, and AD brains. RESULTS We identified 270 distinct
differentially methylated regions (DMRs) associated with AD. We quantified the impact of …
with Alzheimer's disease (AD) but there is a lack of systematic study of the impact of
methylomic alterations over the molecular networks underlying AD. METHODS We profiled
genome‐wide methylomic variations in the parahippocampal gyrus from 201 post mortem
control, mild cognitive impaired, and AD brains. RESULTS We identified 270 distinct
differentially methylated regions (DMRs) associated with AD. We quantified the impact of …
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