Genome-wide DNA methylation analysis to define pulmonary antibody-mediated rejection (AMR) treatment response
Purpose Lung transplant patients with AMR often fail treatment. Defining the mechanisms
involved may identify better drug targets, as well as biomarkers that can be used to tailor
therapies and prevent downstream chronic lung allograft dysfunction (CLAD). Here, we
perform whole-genome DNA methylome analysis to define the mechanisms associated to
AMR non-responders. Methods The case-control design included 26 patients with AMR and
21 controls, matched for race, sex and age. Measurement DNA was extracted from BAL cells …
involved may identify better drug targets, as well as biomarkers that can be used to tailor
therapies and prevent downstream chronic lung allograft dysfunction (CLAD). Here, we
perform whole-genome DNA methylome analysis to define the mechanisms associated to
AMR non-responders. Methods The case-control design included 26 patients with AMR and
21 controls, matched for race, sex and age. Measurement DNA was extracted from BAL cells …
以上显示的是最相近的搜索结果。 查看全部搜索结果