The closely regulated process of mRNA translation is crucial for precise control of protein
abundance and quality. Ribosome profiling, a combination of ribosome foot-printing and
RNA deep sequencing, has been used in a large variety of studies to quantify genome-wide
mRNA translation. Here, we developed Xtail, an analysis pipeline tailored for ribosome
profiling data that comprehensively and accurately identifies differentially translated genes
in pairwise comparisons. Applied on simulated and real datasets, Xtail exhibits high …