Genomic Analyses Reveal the Common Occurrence and Complexity of Plasmodium vivax Relapses in Cambodia

J Popovici, LR Friedrich, S Kim, S Bin, V Run, D Lek… - MBio, 2018 - Am Soc Microbiol
vivax parasites and might therefore carry a much … genomic analyses of a tightly controlled
field study that enabled investigating relapses from individuals residing in a region of malaria

Resolving the cause of recurrent Plasmodium vivax malaria probabilistically

AR Taylor, JA Watson, CS Chu, K Puaprasert… - Nature …, 2019 - nature.com
Genetic analyses complement time-to-recurrence data by … is consistent with occasional
relapses occurring randomly (ie … complexity under the genetic model prevented analysis of six), …

A High Resolution Case Study of a Patient with Recurrent Plasmodium vivax Infections Shows That Relapses Were Caused by Meiotic Siblings

AT Bright, MJ Manary, R Tewhey… - PLoS neglected …, 2014 - journals.plos.org
… literature have shown that relapses occurring in patients with … unable to fully describe the
complex genetic structure of P. … Further genomic analysis of the two definitive relapse samples …

[HTML][HTML] Global epidemiology of Plasmodium vivax

RE Howes, KE Battle, KN Mendis… - The American journal …, 2016 - ncbi.nlm.nih.gov
… The regular occurrence of P. … the fears of potential primaquine-induced hemolysis that
sharply impede its effectiveness, highlight the complexity and difficulty that relapse brings to P. …

Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax

DN Hupalo, Z Luo, A Melnikov, PL Sutton, P Rogov… - Nature …, 2016 - nature.com
… We restricted our population genetic analyses of diversity … We filtered SNP variants in
single and complex infections … set and sites occurring in members of the highly repetitive P. …

Recrudescence, Reinfection, or Relapse? A More Rigorous Framework to Assess Chloroquine Efficacy for Plasmodium vivax Malaria

J Popovici, L Pierce-Friedrich, S Kim… - The Journal of …, 2019 - academic.oup.com
vivax parasites were eliminated in all patients by day 3. Genomic analyses revealed that all
clones in … , clinical assessment of drug efficacy is complicated by the difficulty to disentangle …

Management of relapsing Plasmodium vivax malaria

CS Chu, NJ White - Expert review of anti-infective therapy, 2016 - Taylor & Francis
vivax is shown as occurring across Africa, it is rare west of Uganda in Southern and Eastern
… Proposed mechanism and sequence of Plasmodium vivax relapse activation in a malaria

Single-nucleotide polymorphisms and genome diversity in Plasmodium vivax

X Feng, JM Carlton, DA Joy, J Mu… - Proceedings of the …, 2003 - National Acad Sciences
… basic biology and genome diversity of P. vivax, primarily because of the difficulty of working
with … to important parasite phenotypes such as drug resistance and relapse patterns (15–19). …

Genome-Wide Patterns of Genetic Polymorphism and Signatures of Selection in Plasmodium vivax

OE Cornejo, D Fisher… - Genome biology and …, 2015 - academic.oup.com
… However, as is the case in many complex processes, such genomic patterns are seldom the
… OEC codesigned and performed the population genomic analyses and wrote a first draft of …

High Proportion of Genome-Wide Homology and Increased Pretreatment pvcrt Levels in Plasmodium vivax Late Recurrences: a Chloroquine Therapeutic Efficacy …

…, NTH Binh, NTH Ngọc, P Guetens… - Antimicrobial agents …, 2021 - Am Soc Microbiol
vivax relapses in tropical areas also showed that recrudescent … Second, genetic analysis
revealed a remarkably high … High complexity of Plasmodium vivax infections in symptomatic …