Colorectal cancer arises as a consequence of the accumulation of genetic alterations (gene
mutations, gene amplification, and so on) and epigenetic alterations (aberrant DNA
methylation, chromatin modifications, and so on) that transform colonic epithelial cells into
colon adenocarcinoma cells. The loss of genomic stability and resulting gene alterations are
key molecular pathogenic steps that occur early in tumorigenesis; they permit the acquisition
of a sufficient number of alterations in tumor suppressor genes and oncogenes that …

: Colorectal Cancer (CRC) is the third most common cancer in men and the second most
common cancer in women worldwide. Both genetic and epigenetic alterations are common
in CRC and are the driving force of tumorigenesis. Chromosomal instability, microsatellite
instability and CpG island methylator phenotype pathways are responsible for genetic
instability in colorectal cancer. Chromosomal instability pathway consists of activation of
proto-oncogenes and inactivation of tumor suppression genes and Loss of Heterozogosity …