Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma
A Reuben, CN Spencer, PA Prieto… - NPJ genomic …, 2017 - nature.com
Appreciation for genomic and immune heterogeneity in cancer has grown though the
relationship of these factors to treatment response has not been thoroughly elucidated. To
better understand this, we studied a large cohort of melanoma patients treated with targeted
therapy or immune checkpoint blockade (n= 60). Heterogeneity in therapeutic responses via
radiologic assessment was observed in the majority of patients. Synchronous melanoma
metastases were analyzed via deep genomic and immune profiling, and revealed …
relationship of these factors to treatment response has not been thoroughly elucidated. To
better understand this, we studied a large cohort of melanoma patients treated with targeted
therapy or immune checkpoint blockade (n= 60). Heterogeneity in therapeutic responses via
radiologic assessment was observed in the majority of patients. Synchronous melanoma
metastases were analyzed via deep genomic and immune profiling, and revealed …
以上显示的是最相近的搜索结果。 查看全部搜索结果