Genotoxicity and morphological changes induced by the alkaloid monocrotaline, extracted from Crotalaria retusa, in a model of glial cells
JP Silva-Neto, RA Barreto, BPS Pitanga, CS Souza… - Toxicon, 2010 - Elsevier
Plants of Crotalaria genus (Leguminosae) present large amounts of the pyrrolizidine
alkaloid monocrotaline (MCT) and cause intoxication to animals and humans. Therefore, we
investigated the MCT-induced cytotoxicity, morphological changes, and oxidative and
genotoxic damages to glial cells, using the human glioblastoma cell line GL-15 as a model.
The comet test showed that 24h exposure to 1–500μM MCT and 500μM
dehydromonocrotaline (DHMC) caused significant increases in cell DNA damage index …
alkaloid monocrotaline (MCT) and cause intoxication to animals and humans. Therefore, we
investigated the MCT-induced cytotoxicity, morphological changes, and oxidative and
genotoxic damages to glial cells, using the human glioblastoma cell line GL-15 as a model.
The comet test showed that 24h exposure to 1–500μM MCT and 500μM
dehydromonocrotaline (DHMC) caused significant increases in cell DNA damage index …
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