Genotoxicity of 3′-azido-3′-deoxythymidine in the human lymphoblastoid cell line, TK6: relationships between DNA incorporation, mutant frequency, and spectrum …
HE Sussman, OA Olivero, Q Meng, SM Pietras… - Mutation Research …, 1999 - Elsevier
Perinatal treatment with 3′-azido-3′-deoxythymidine (AZT) has been found to reduce the
rate of maternal–infant transmission of HIV; however, AZT is genotoxic in mammalian cells in
vitro and induces tumors in the offspring of mice treated in utero. The purpose of the present
study was to investigate the relationships between incorporation of AZT into DNA, and the
frequency and spectrum of mutations at the HPRT locus of the human lymphoblastoid cell
line, TK6, following in vitro exposures to AZT. Cells were cultured in medium containing 0 or …
rate of maternal–infant transmission of HIV; however, AZT is genotoxic in mammalian cells in
vitro and induces tumors in the offspring of mice treated in utero. The purpose of the present
study was to investigate the relationships between incorporation of AZT into DNA, and the
frequency and spectrum of mutations at the HPRT locus of the human lymphoblastoid cell
line, TK6, following in vitro exposures to AZT. Cells were cultured in medium containing 0 or …
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