[HTML][HTML] Germinal BRCA1-2 pathogenic variants (gBRCA1-2pv) and pancreatic cancer: epidemiology of an Italian patient cohort
Objective Germline BRCA1-2 pathogenic variants (gBRCApv) increase the risk of pancreatic
cancer and predict for response to platinating agents and poly (ADP-ribose) polymerase
inhibitors. Data on worldwide gBRCApv incidence among pancreatic ductal
adenocarcinoma (PDAC) patients are sparse and describe a remarkable geographic
heterogeneity. The aim of this study is to analyze the epidemiology of gBRCApv in Italian
patients. Materials and methods Patients of any age with pancreatic adenocarcinoma …
cancer and predict for response to platinating agents and poly (ADP-ribose) polymerase
inhibitors. Data on worldwide gBRCApv incidence among pancreatic ductal
adenocarcinoma (PDAC) patients are sparse and describe a remarkable geographic
heterogeneity. The aim of this study is to analyze the epidemiology of gBRCApv in Italian
patients. Materials and methods Patients of any age with pancreatic adenocarcinoma …
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