Glucagon, GLP-1 and thermogenesis

I González-García, E Milbank, C Diéguez… - International journal of …, 2019 - mdpi.com
… , glucagon and glucagon-like peptide 1 (GLP-1) have been associated in recent years with
BAT thermogenesis, … , whether glucagon has a direct action on BAT thermogenesis requires …

GLP-1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK

D Beiroa, M Imbernon, R Gallego, A Senra… - Diabetes, 2014 - Am Diabetes Assoc
… We report that the CNS GLP-1 system directly activates BAT thermogenesis and browning
of white adipocytes. The primary finding is that these actions are mediated by hypothalamic …

The effects of glucagon-like peptide type 1 (glp-1) and its analogues in adipose tissue: is there a way to thermogenesis?

I Stafeev, E Sorkina, E Koksharova… - Current Molecular …, 2021 - ingentaconnect.com
GLP1 receptor was found in subcutaneous fat tissue. Thirdly, there is data on GLP-1-induced
systemic thermogenesis… of GLP-1 action in fat tissue, stimulating thermogenesis and beige …

Hypothalamic GLP-1: the control of BAT thermogenesis and browning of white fat

M López, C Diéguez, R Nogueiras - Adipocyte, 2015 - Taylor & Francis
… By doing an acute central injection of a GLP-1 receptor agonist, namely liraglutide, we
confirmed previous results indicating that the brain GLP-1 system increases the thermogenic

Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling

SH Lockie, KM Heppner, N Chaudhary… - Diabetes, 2012 - Am Diabetes Assoc
… The increase in the iBAT thermogenesis induced by ICV OXM is consistent with its partial
agonism on the GCGR; however, here we show that ICV GLP-1 increases iBAT thermogenesis, …

Glucagon-like peptide-1 regulates brown adipose tissue thermogenesis via the gut-brain axis in rats

JP Krieger, EP Santos da Conceição… - American Journal …, 2018 - journals.physiology.org
… control of BAT thermogenesis. Collectively, our results support a novel diet-dependent
role of endogenous intestinal GLP-1 that fine-tunes EE and BAT thermogenesis via a gut-brain …

Glucagon‐like Peptide‐1 Improves Fatty Liver and Enhances Thermogenesis in Brown Adipose Tissue via Inhibiting BMP4‐Related Signaling Pathway in High‐Fat …

X Wang, B Ma, J Chen, H You, C Sheng… - International Journal …, 2021 - Wiley Online Library
… adipose tissue in the GLP-1 treated group when compared to the control group. These
results indicate that GLP-1 may increase thermogenesis by decreasing the expression of BMP4. …

[HTML][HTML] Loss of dorsomedial hypothalamic GLP-1 signaling reduces BAT thermogenesis and increases adiposity

SJ Lee, G Sanchez-Watts, JP Krieger, A Pignalosa… - Molecular …, 2018 - Elsevier
… stimulation increased BAT thermogenesis and hepatic fuel … neuronal regulation of BAT
thermogenesis. Collectively, our … the central GLP-1 system that controls BAT thermogenesis in …

Is glucagon receptor activation the thermogenic solution for treating obesity?

E Conceição-Furber, T Coskun, KW Sloop… - Frontiers in …, 2022 - frontiersin.org
… activation augments metabolic rate and stimulates a right-shift in the weight loss curve
induced by selective GLP-1R and dual GIP and GLP-1 receptor agonism in obese mice (17, 20). …

The effect of glucagon-like peptide 1 and glucagon-like peptide 1 receptor agonists on energy expenditure: A systematic review and meta-analysis

MG Maciel, BTS Beserra, FCB Oliveira… - Diabetes Research and …, 2018 - Elsevier
… We included clinical trials that investigated the effects of GLP-1 or GLP-1RA on the following
components of EE: resting EE (REE) or basal metabolic rate, diet-induced thermogenesis (…