Glucagon-like peptide 1 reduces endothelial dysfunction, inflammation, and oxidative stress induced by both hyperglycemia and hypoglycemia in type 1 diabetes
A Ceriello, A Novials, E Ortega, S Canivell… - Diabetes …, 2013 - Am Diabetes Assoc
Diabetes care, 2013•Am Diabetes Assoc
OBJECTIVE Hyperglycemia and hypoglycemia currently are considered risk factors for
cardiovascular disease in type 1diabetes. Both acute hyperglycemia and hypoglycemia
induce endothelial dysfunction and inflammation, raising the oxidative stress. Glucagon-like
peptide 1 (GLP-1) has antioxidant properties, and evidence suggests that it protects
endothelial function. RESEARCH DESIGN AND METHODS The effect of both acute
hyperglycemia and acute hypoglycemia in type 1 diabetes, with or without the simultaneous …
cardiovascular disease in type 1diabetes. Both acute hyperglycemia and hypoglycemia
induce endothelial dysfunction and inflammation, raising the oxidative stress. Glucagon-like
peptide 1 (GLP-1) has antioxidant properties, and evidence suggests that it protects
endothelial function. RESEARCH DESIGN AND METHODS The effect of both acute
hyperglycemia and acute hypoglycemia in type 1 diabetes, with or without the simultaneous …
OBJECTIVE
Hyperglycemia and hypoglycemia currently are considered risk factors for cardiovascular disease in type 1diabetes. Both acute hyperglycemia and hypoglycemia induce endothelial dysfunction and inflammation, raising the oxidative stress. Glucagon-like peptide 1 (GLP-1) has antioxidant properties, and evidence suggests that it protects endothelial function.
RESEARCH DESIGN AND METHODS
The effect of both acute hyperglycemia and acute hypoglycemia in type 1 diabetes, with or without the simultaneous infusion of GLP-1, on oxidative stress (plasma nitrotyrosine and plasma 8-iso prostaglandin F2alpha), inflammation (soluble intercellular adhesion molecule-1 and interleukin-6), and endothelial dysfunction has been evaluated.
RESULTS
Both hyperglycemia and hypoglycemia acutely induced oxidative stress, inflammation, and endothelial dysfunction. GLP-1 significantly counterbalanced these effects.
CONCLUSIONS
These results suggest a protective effect of GLP-1 during both hypoglycemia and hyperglycemia in type 1 diabetes.
Am Diabetes Assoc
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