Glutamate regulates Ca2+ signals in smooth muscle cells of newborn piglet brain slice arterioles through astrocyte- and heme oxygenase-dependent mechanisms
Q Xi, E Umstot, G Zhao, D Narayanan… - American Journal …, 2010 - journals.physiology.org
Glutamate is the principal cerebral excitatory neurotransmitter and dilates cerebral arterioles
to match blood flow to neural activity. Arterial contractility is regulated by local and global
Ca2+ signals that occur in smooth muscle cells, but modulation of these signals by
glutamate is poorly understood. Here, using high-speed confocal imaging, we measured the
Ca2+ signals that occur in arteriole smooth muscle cells of newborn piglet tangential brain
slices, studied signal regulation by glutamate, and investigated the physiological function of …
to match blood flow to neural activity. Arterial contractility is regulated by local and global
Ca2+ signals that occur in smooth muscle cells, but modulation of these signals by
glutamate is poorly understood. Here, using high-speed confocal imaging, we measured the
Ca2+ signals that occur in arteriole smooth muscle cells of newborn piglet tangential brain
slices, studied signal regulation by glutamate, and investigated the physiological function of …
Glutamate regulates Ca 2 signals in smooth muscle cells 3 of newborn piglet brain slice arterioles through astrocyte-and 4 heme oxygenase-dependent mechanisms …
Q Xi, E Umstot, G Zhao, D Narayanan, CW Leffler… - 2009 - journals.physiology.org
Glutamate is the principal cerebral excitatory neurotransmitter and dilates cerebral arterioles
to 26 match blood flow to neural activity. Arterial contractility is regulated by local and global
27 calcium (Ca2+) signals that occur in smooth muscle cells, but modulation of these signals
by 28 glutamate is poorly understood. Here, using high-speed confocal imaging we
measured Ca2+ 29 signals that occur in arteriole smooth muscle cells of newborn piglet
tangential brain slices, 30 studied signal regulation by glutamate, and investigated the …
to 26 match blood flow to neural activity. Arterial contractility is regulated by local and global
27 calcium (Ca2+) signals that occur in smooth muscle cells, but modulation of these signals
by 28 glutamate is poorly understood. Here, using high-speed confocal imaging we
measured Ca2+ 29 signals that occur in arteriole smooth muscle cells of newborn piglet
tangential brain slices, 30 studied signal regulation by glutamate, and investigated the …
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