Glycans at the forefront of cells facilitate immune recognition processes. Cancer cells
commonly present altered cell surface glycosylation, especially manifested in the expression
of sialic acid at the termini of glycolipids and glycoproteins. Although tumor-associated
carbohydrate antigens (TACAs) result in expression of altered-self, most such carbohydrates
do not elicit strong humoral responses. Various strategies had been devised to elicit
increased immunogenicity of such TACA aiming for potent immunotherapeutic antibodies or …