Gold nanoparticles capped with sulfate-ended ligands as anti-HIV agents
P Di Gianvincenzo, M Marradi… - Bioorganic & medicinal …, 2010 - Elsevier
Bioorganic & medicinal chemistry letters, 2010•Elsevier
Gold nanoparticles coated with multiple copies of an amphiphilic sulfate-ended ligand are
able to bind the HIV envelope glycoprotein gp120 as measured by surface plasmon
resonance (SPR) and inhibit in vitro the HIV infection of T-cells at nanomolar concentrations.
A 50% density of sulfated ligands on∼ 2nm nanoparticles (the other ligands being inert
glucose derivatives) is enough to achieve high anti-HIV activities. This result opens up the
possibility of tailoring both sulfated ligands and other anti-HIV molecules on the same gold …
able to bind the HIV envelope glycoprotein gp120 as measured by surface plasmon
resonance (SPR) and inhibit in vitro the HIV infection of T-cells at nanomolar concentrations.
A 50% density of sulfated ligands on∼ 2nm nanoparticles (the other ligands being inert
glucose derivatives) is enough to achieve high anti-HIV activities. This result opens up the
possibility of tailoring both sulfated ligands and other anti-HIV molecules on the same gold …
Gold nanoparticles coated with multiple copies of an amphiphilic sulfate-ended ligand are able to bind the HIV envelope glycoprotein gp120 as measured by surface plasmon resonance (SPR) and inhibit in vitro the HIV infection of T-cells at nanomolar concentrations. A 50% density of sulfated ligands on ∼2nm nanoparticles (the other ligands being inert glucose derivatives) is enough to achieve high anti-HIV activities. This result opens up the possibility of tailoring both sulfated ligands and other anti-HIV molecules on the same gold cluster, thus contributing to the development of non-cocktail based multifunctional anti-HIV systems.
Elsevier
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