Granulomatous nephritis and dermatitis in a patient with BRAF V600E mutant metastatic melanoma treated with dabrafenib and trametinib
YJ Jansen, P Janssens, A Hoorens… - Melanoma …, 2015 - journals.lww.com
A 61-year-old man was diagnosed with stage IIIB BRAF V600E mutant melanoma in October
2012. He was treated with a combination therapy of dabrafenib and trametinib. He remained
in complete remission for 18 months and the treatment was well tolerated after dose
reduction because of pyrexia. In March 2013, he developed bilateral pitting edema of the
legs with an erythematous, slightly infiltrated rash on his back and upper arms. His face was
edematous, with a heliotrope rash-like aspect. Eye examination showed bilateral blepharitis …
2012. He was treated with a combination therapy of dabrafenib and trametinib. He remained
in complete remission for 18 months and the treatment was well tolerated after dose
reduction because of pyrexia. In March 2013, he developed bilateral pitting edema of the
legs with an erythematous, slightly infiltrated rash on his back and upper arms. His face was
edematous, with a heliotrope rash-like aspect. Eye examination showed bilateral blepharitis …
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