Karst aquifer is an important water resource in southern France. It is the main source for agriculture and for domestic water supply. Hence, it is necessary to assess the quantity and quality of water in the Bleone Catchment. In order to achieve this aim, a groundwater chemistry analysis and regional numerical groundwater flow modelling using MODFLOW were conducted. Groundwater samples from springs and wells analyzed for water quality in the Bléone Catchment demonstrate different water types dominated mostly by fresh water, which is of moderate alkalinity and contains calcium and magnesium as major cations and bicarbonate as a common anion. The saturation indices for calcite and dolomite reveal that dissolution of calcite and dolomite can still take place. In addition, there is a very complex interaction between surface water and groundwater in the catchment.