To illustrate the process of developing and sustaining an academic‐public health partnership for behavioral health integration through an expansion of the Aligning Systems for Health (ASfH) framework.

Practice‐informed primary data (2017–2023) from the Holistic Opportunity Program for Everyone (HOPE) Initiative based in Charlotte, NC.

The unit of analysis in this descriptive case study is inter‐organizational, specifically focusing on an academic‐public health relationship. We illustrate the partnership process across the ASfH four core areas, including key challenges and insights.

Utilized a Critical Moments Reflection methodology and review of HOPE program data.

(1) Formal partnership structures and processes are essential to monitoring the four ASfH core components for on‐going system alignment. (2) Aligning systems for health principally involves two ecologies: (i) the health program and (ii) the partnership. The vitality and sustainability of both ecologies require continuous attention and resource investment. (3) Relationships rest at the heart of aligning systems. (4) With comparative advantages in research methods, the academic sector is especially poised to collaborate with healthcare systems and human service organizations to study, develop, implement, and scale evidence‐based health interventions.

The academic sector shares overlapping purposes with the public health, healthcare, and social services sectors while providing complementary value. It is a critical sectoral partner in advancing population health and health equity.