The global epidemic of tuberculosis (TB) imposes a sustained epidemiologic vigilance and
investments in research by governments. Mycobacterium tuberculosis, the main causative
agent of TB in human beings, is a very successful pathogen, being the main cause of death
in the population among infectious agents. In 2018,~ 10 million individuals were
contaminated with this bacillus and became ill with TB, and about 1.2 million succumbed to
the disease. Most of the success of the M. tuberculosis to linger in the population comes from …

Human tuberculosis (TB), mainly caused by the bacterial pathogen Mycobacterium
tuberculosis, is a chronic, infectious-contagious, and deadly disease that has reached
pandemic proportions. Typically, the active form of the disease affects the lungs (pulmonary
TB) but in∼ 25% of patients (immunocompromised patients or children) mycobacteria may
enter the blood stream and infect other parts of the body such as the pleura, the meninges,
the lymphatic system, the genitourinary system, bones, and joints (Smith, 2003). The World …