Energy efficiency (EE) and renewable energy (RE) can benefit public health and the climate by displacing emissions from fossil-fuelled electrical generating units (EGUs). Benefits can vary substantially by EE/RE installation type and location, due to differing electricity generation or savings by location, characteristics of the electrical grid and displaced power plants, along with population patterns. However, previous studies have not formally examined how these dimensions individually and jointly contribute to variability in benefits across locations or EE/RE types. Here, we develop and demonstrate a high-resolution model to simulate and compare the monetized public health and climate benefits of four different illustrative EE/RE installation types in six different locations within the Mid-Atlantic and Lower Great Lakes of the United States. Annual benefits using central estimates for all pathways ranged from US$5.7–US$210 million (US$14–US$170 MWh⁻¹), emphasizing the importance of site-specific information in accurately estimating public health and climate benefits of EE/RE efforts.