Pain is one of the most severe and debilitating symptoms associated with several forms of
cancer,. Various types of carcinomas and sarcomas metastasize to skeletal bones and
cause spontaneous bone pain and hyperalgesia, which is accompanied by bone
degradation and remodeling of peripheral nerves. Despite recent advances, the molecular
mechanisms underlying the development and maintenance of cancer-evoked pain are not
well understood. Several types of non-hematopoietic tumors secrete hematopoietic colony …

311 HEMATOPOIETIC COLONY STIMULATING FACTORS MEDIATE TUMOR‐NERVE
INTERACTIONS AND BONE CANCER PAIN - Njoo - 2009 - European Journal of Pain -
Wiley Online Library …