Lipid droplets (LDs) are energy-storage organelles that are coated with hundreds of
proteins, including members of the perilipin (PLIN) family. PLIN5 is highly expressed in
oxidative tissues, including the liver, and is thought to play a key role in uncoupling LD
accumulation from lipotoxicity; however, the mechanisms behind this action are incompletely
defined. We investigated the role of hepatic PLIN5 in inflammation and lipotoxicity in a
murine model under both fasting and refeeding conditions and in hepatocyte cultures. PLIN5 …