Hepatitis E Virus–associated meningoencephalitis in a lung transplant recipient diagnosed by clinical metagenomic sequencing
JA Murkey, KW Chew, M Carlson… - Open forum …, 2017 - academic.oup.com
Open forum infectious diseases, 2017•academic.oup.com
Hepatitis E virus (HEV) infection uncommonly causes chronic hepatitis and neurologic
disease. We describe a case of genotype 3a HEV meningoencephalitis diagnosed by
metagenomic next-generation sequencing, illustrating the power of an unbiased molecular
approach to microbial testing and the first reported case of HEV infection presumably
acquired through lung transplantation.
disease. We describe a case of genotype 3a HEV meningoencephalitis diagnosed by
metagenomic next-generation sequencing, illustrating the power of an unbiased molecular
approach to microbial testing and the first reported case of HEV infection presumably
acquired through lung transplantation.
Abstract
Hepatitis E virus (HEV) infection uncommonly causes chronic hepatitis and neurologic disease. We describe a case of genotype 3a HEV meningoencephalitis diagnosed by metagenomic next-generation sequencing, illustrating the power of an unbiased molecular approach to microbial testing and the first reported case of HEV infection presumably acquired through lung transplantation.
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